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Information × Registration Number 0207U005376, 0104U002758 , R & D reports Title Biophysical mechanisms of neurons output signal's structure formation. popup.stage_title Head Korogod Sergiy M., Registration Date 04-04-2007 Organization International center of molecular physiology popup.description2 Models of neocortical pyramidal and cerebellar Purkinje neurons were developed with reconstructed dendritic arborizations and prototype-like cocktails of active membrane conductances. Output discharge patterns were compared in response to tonic synaptic excitation homogeneously distributed over the dendrites. It was found that the richness of repertoire of the discharge patterns is related to complexity and metrical asymmetry of the dendritic arborization and changes with intensity of tonic excitation. Simple patterns were generated with synaptic conductance in low and high ranges, whereas complex multiple patterns required medium intensities. Spatial signatures of the simple patterns were similar electrical states of asymmetrical dendritic subtrees, whereas those of the complex patterns were combinations of different states of the subtrees. The data show earlier unknown features of the dendritic computations, which might have important fundamental and applied impacts. Product Description popup.authors popup.nrat_date 2020-04-02 Close