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Information × Registration Number 0207U005377, 0104U002759 , R & D reports Title Changes in synaptic transmission effectiveness during the different leves of nervous system under the experimentally induced pathologies. popup.stage_title Head Kostyuk Platon Gr., Registration Date 04-04-2007 Organization International center of molecular physiology popup.description2 The received data can be considered as the essential contribution to understanding of a nature of occurrence diabetes neuropathologies. Their essential component are the infringements intracellular of an exchange of ions calcium in primary and secondary sensory neurones of ways nociception of sensitivity at the expense of change of the appropriate activity endoplazmatic reticculum and mitochondrias. These changes in turn result in changes of synapses transfer of signals in maximum brain structures, that in turn results in occurrence pain syndromes. Therefore, the further study of molecular mechanisms of these changes can have essential meaning for understanding of a nature neuropathologies and search of effective ways of their correction. The conclusion that frequency of spontaneous spine activity in hypocampal cultured neurons depends on the balance between inhibitory and excitatory synaptic transmission as well as on the glucose concentration in extracellular solution. Product Description popup.authors popup.nrat_date 2020-04-02 Close