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Information × Registration Number 0207U005845, 0104U007733 , R & D reports Title Biotechnology of production of the new anticancer antibiotic landomycin E on the basis of genetic and genetic engineering approach popup.stage_title Head Matselyukh Bogdan Pavlovich, Registration Date 06-07-2007 Organization Zabolotny Institute of Microbiology and Virology Ukrainian NAS popup.description2 Fragment of chromosomal DNA (7,5 kb) of Streptomyces globisporus 1912 containing 5 genes of landomycin E biosynthesis was cloned in plasmid vector. Protoplasts of antibiotic inactive strains were transformed by recombinant plasmid and high active clones - producers of landomycin E were selected. Cultivation of these strains on optimal medium in laboratory fermenter was resulted in production of 200 mg/L of purified landomycin E Product Description popup.authors popup.nrat_date 2020-04-02 Close