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Information × Registration Number 0207U006106, 0106U011304 , R & D reports Title The studing of morphocytochemical, immunophenotype and molecular-genetic patterns of hematopoietic progenitor cells as targets for malignant transformation in acute leukemias. Identification of receptor-mediated signal transduction pathways that are involved in regulation of terminal stages of B lymphocyte differentiation. popup.stage_title Head Gluzman Daniil Fishelevich, Sidorenko Svitlana Pavlovna, Registration Date 16-03-2007 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 We determined morphocytochemical, immunophenotype and molecular-genetic feature of hematopoietic progenitor cells first-third line. We defined markers do identify this not numerous cells and described analogue of leukemia cells.To explore the contribution of CD150 to BCR induced changes in gene expression we carried out a series of gene microarray experiments using cDNA two-color chip. The analysis of microarray data revealed that CD150 significantly alter BCR induced changes in DT40 gene expression profile, by changing expression level of at least 67 array elements that are encoded by 54 unique genes compared to antigen-activated control DT40 pApuro cells Product Description popup.authors popup.nrat_date 2020-04-02 Close