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Information × Registration Number 0207U006578, 0104U008938 , R & D reports Title Experimental elaboration of a new approaches and treatment of oogenesis distarbances under immune ovary pathology popup.stage_title Head Makogon Nataliya Volodymyrivna, Registration Date 08-06-2007 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 Two models of autoimmune ovaries injury in mice have been created and characterized: 1) a model of antibody origin, using xenogenic anti-ovary antibodies, and 2) a model of mixed antibody-cellular origin, achieved by immunizing mice with the tissue of allogenic ovary. Both types of injury caused inhibition of oocyte meiotic maturation, the increased death of follicular cells and those of thymus and lymph nodes. The donor of nitric oxide molsidomin exerted a protective effect on the oocyte maturation and follicular cells survival in both models. In contrast, epiphysis hormone melatonin favored oocyte maturation and decreased the apoptotic death of follicular and immunocompetent cells in case of xenogenic anti-ovary antibodies application only. It is concluded that nitric oxide donors as well as melatonin can be regarded as potential medications upon some types of autoimmune ovary injury.5635 Product Description popup.authors popup.nrat_date 2020-04-02 Close