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Information × Registration Number 0207U006582, 0104U008941 , R & D reports Title The investigation of cardioprotection properties of the new domestic activators of ATP-dependent potassium chennels popup.stage_title Head Moybenko Olexiy Olexiyovich, Registration Date 08-06-2007 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 We studied the effects of the new fluorine-containing openers of KATP channels - flokalin, PF-10, diazoxide-Fp and diazoxide-Fm on isolated hearts perfused by Langendorff. The tested agents decrease resistance of the coronary vessels in a dose-dependent manner, and attenuate spontaneous alterations of the heart rate. Preliminary activation of KATP channels by PF-10, flokalin and diazoxide-Fm exert cardioprotective effects under conditions of ischemia-reperfusion (similarly to the well-known phenomenon of ischemic preconditioning). Our results allow us to believe that the tested substances can be considered as effective regulators of the vascular tone and heart function.5635 Product Description popup.authors popup.nrat_date 2020-04-02 Close