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Information × Registration Number 0207U010271, 0105U002436 , R & D reports Title То аssay age-related differences of glytathione metabolism in visceral tissues during immobilization stress popup.stage_title Head Davydov Vadim Viacheslavovich, Кандидат технічних наук Registration Date 11-01-2008 Organization Ukrainian Research Institute of Children and Adolescents Health Care popup.description2 Research object: oxidative stress, the content of oxidized and reduced glutathione (G), and fermental activity of the first line antioxidant brain protection. Objective: studying age-related features of the G system state in the brain of rats subjected to immobilization stress. Methods, equipment: spectrophotometry, differential centrifugation, SP-46 spectrophotometer, refrigerating centrifugal machine. Theorical and practical results: it has been established that in one-month-old rats the content of reduced G is much lower than in older animals. The significance of G in brain protection from stress stimulation of free radical processes changes in the course of ontogenesis. In pubertal age it decreases, and after puberty (at the age of 2 months) and up to late ontogenesis (24 months of age) it increases significantly. Novelty: the role of G system in age-related changes of the organism resistance to oxidative stress has been established in the study which fact can contribute to extending the notionson mechanisms connected with age-related pathology formation, and to developing effective ways of its prophylaxis in puberty by using medications to correct the level of reduced G. Application fields: medical biochemistry. Product Description popup.authors popup.nrat_date 2020-04-02 Close