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Information × Registration Number 0208U000027, 0105U000903 , R & D reports Title Investigation of possibilities for correction of structural and functional changes in traumatic brain injury by means of gene therapy popup.stage_title Head Pedachenko E.G., Registration Date 08-01-2008 Organization SI "Institute of neurosurgery named after acad. A.P. Romodanov of Academy of Medical Sciences of Ukraine" popup.description2 The research was performed on the experimental animals (rats) in which traumatic brain injury had been reproduced using the "impact acceleration model". After the trauma the intracerebroventricular infusion of cationic liposomes contained the plasmid vector with human APOE2 or APOE3 genes was carried out. The effectiveness of transfection was confirmed by RT-PCR. The synthesis of apolipoprotein E in brain cells promoted the regress of trauma-induced structural changes, enhanced the viability of neurons, specifically in hippocampus. Gene therapy promoted more rapid regress of motor and cognitive (space memory) disorders after experimental traumatic brain injury. Product Description popup.authors popup.nrat_date 2020-04-02 Close