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Information × Registration Number 0208U004109, 0107U007196 , R & D reports Title The role of system of gamma-aminobutyric acid transport in maintenance of functional competence of human spermatozoa popup.stage_title Head Linetska M.V., Registration Date 14-02-2008 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 The experiments have shown that human spermatozoa are able to effectively accumulate GABA. Although the rate of this process is lower than that of the GABA transport into the nerve endings. Kinetic parameters of the work of the plasma membrane GABA-transporter on human spermatozoa were shown. Кm = 12±2 mcM and Vmax = 4568±1002 fmol/10 mln. cells/min. For the first time for the human spermatozoa we demonstrated the functioning of acrosome-specific V-ATPase, which acidifies acrosomal lumina. For the first time evidence were obtained that H+-ATPase, generating proton gradient across acrosomal membrane, plays an important role in the GABA transport into acrosome and its redistribution between the intracellular pools. Product Description popup.authors popup.nrat_date 2020-04-02 Close