Search academic texts

Information × Registration Number 0208U004388, 0105U003467 , R & D reports Title Receptor mechanisms of peripheral antinociception popup.stage_title Head Krishtal Oleg O., Доктор біологічних наук Registration Date 06-06-2008 Organization International center of molecular physiology popup.description2 For the duration of accounting period within the framework of SIW the "receptor mechanisms of peripheral antinociception" were conducted intensive studies dedicated to the molecular mechanisms of nociception and antinociception. The primary attention of these studies was focused on the gating mechanisms of P2X the receptors, namely sensitivity P2X to the temperature changes, the redox-agents; and to the action of various constituents from the poisons of arthropods, endogenous opioids, cannabinoids on these receptors. Also were performed the thorough studies of the modulation of high-threshold calcium channels by endogenous opioids, cannabinoids and poisons constituents. As a result of the carried out works it was shown that P2X3 receptors (both directly and mediately) can be the new amazingly temperature-dependent molecular target for the peripheral pain treatment. We showed that the high-threshold calcium channels are modulated by cannabinoids without the participati on of heterotrimeric G-proteins that also points on the fundamentally new molecular target in peripheral antinociception Product Description popup.authors popup.nrat_date 2020-04-02 Close