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Information × Registration Number 0208U004727, 0108U010659 , R & D reports Title Chaperone-like properties of mammalian translational elongation factor 1A (eEF1A) popup.stage_title Head Lukash T.O., Registration Date 15-12-2008 Organization Institute of molecular biology & genetics popup.description2 The experimental evidences of chaperone-like properties of eEF1A are presented. Structural changes in the PheRS molecules after heat inactivation, determined by the circular dichroism, dynamic light scattering and non-denaturing agarose electrophoresis, comprise change in the total surface charge, protein aggregation and 20 % decrease in alfa- helical structure. eEF1A is shown to restore the total surface charge of PheRS and reduce the level of aggregation similar to molecular chaperones. These capacity of eEF1A might be important for maintaining the active conformations of the protein synthesis components in the translation compartments during consecurive elongation cycles. Product Description popup.authors popup.nrat_date 2020-04-02 Close