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Information × Registration Number 0208U005043, 0108U001515 , R & D reports Title Molecular phisiologic and neuroendocrine mechanisms of hippocampal neuroprotection and anditiabetic effects of glucocorticoid receptors blockers in experimental diabetes mellitus popup.stage_title Head Orlovsky Maxym Olexandrovych, Registration Date 18-03-2008 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 The aim of the present study was to prevent diabetic neuropathy. It was established that streptozotocin diabetes mellitus already at day 3 leads to significant neuronal loss in hippocampus. Diabetic nerodegeneration is closely linked with immunoproteasome gene expression and inducible nitric oxyde synthase activation. Metyrapone during diabetes mellitus in diabetic rats led to the normalization of carbohydrate mathabolism starting from diabetes day 3. In hippocampus metyrapone was able to prevent neuronal loss caused by diabetes mellitus.5635 Product Description popup.authors popup.nrat_date 2020-04-02 Close