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Information × Registration Number 0208U005377, 0105U002854 , R & D reports Title Transplantation of central immunt organs cells by congenital breaches of the immunity and hemoroesis popup.stage_title Head Popov N., Registration Date 22-04-2008 Organization Kharkov national university named after V.N. Karazin popup.description2 A research object are marrow, thymus, spleen, peripheral blood of the radiation-exposed in an embryonic period animals-recipients of allogenic myelocariocytes or syngenic myelocariocytes and lymphocytes of thymus. Purpose of work - on the model of the immunodeficit caused by the x-ray irradiation in low doses in the period of early embriogeny, to define conformities to the law of influencing of transplantation of syngenic and allogenic myelocariocytes and lymphocytes on the postnatal becoming of the immune and hemopoietic systems of animals-recipients. Research methods are cytological, histological, immunological, cytogenetical, biochemical. Structural principle is certain of optimization at new-born posterity of hemopoiesis and immunogenesis broken as a result of pathogenic action of irradiation in a dose 0,5 Gy in a predimplantation period, by transphusion of myelocariocytes and lymphocytes in subtransplantations doses. It is rotined that normalization of the changed parameters of hemopoiesis andimmunity can be attained at the use more high from the investigational doses (0,5?103) of syngenic bone marrow cells and lymphocytes (as models of HLA-mathed cellular therapy) or more low from the investigational doses (1,5?104) of allogenic bone marrow per se (as models of HLA-mathed cellular therapy). Product Description popup.authors popup.nrat_date 2020-04-02 Close