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Information × Registration Number 0208U005518, 0103U000937 , R & D reports Title The role of neuro-immuno-endocrine interactions and its disturbances for experimental and clinical pathology (experimental and clinical investigation) popup.stage_title Head Kolesnik Y. M., Registration Date 02-06-2008 Organization Zaporozhye State Medical University popup.description2 It was determined that development of diabetes mellitus is accompanied by the disorder of differentiation processes and proliferation of lymphocytes in thymus, progressive decrease of their number and increase of the of apoptotic cell number. But introduction of neuropeptide Y or oxytocin promotes establishing of the number of lymphoid population and decrease of apoptotic cell part. It is determined that in the result of prenatal stress glucose tolerance of -endocrino cytes is disturbed and their resistance to -cytotoxic factors decreases. But dosed hypoxic training and use of highly selective blockers of NO synthesis lead to significant increase of -cells resistance and can considerably stimulate processes of new growth of -cells in pancreas and activate insulin synthesis in them. It is proved that prenatal stress results in considerable retardation of differentiation of vasopressin-synthesizing neurons in hypothalamus in the form of decrease of neurons number and suppression of neurohormone synthesis. The study of correlation of functional state of peripheral arteries and some humoral indexes was performed in patients with type II diabetes associated with essential hypertension with the aim of determining of key markers of endothelial dysfunction rising in development of diabetic angiopathy.5635 Product Description popup.authors popup.nrat_date 2020-04-02 Close