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Information × Registration Number 0208U010055, 0106U002351 , R & D reports Title The study of health state of children born in persons irradiated in children's age, and substantiation of methods of its conservation popup.stage_title Head Stepanova Evgenia Ivanovna, Доктор медичних наук Registration Date 26-12-2008 Organization Research Centre for Radiation Medicine popup.description2 Object of research - children who have been born from parents, the irradiated in children's . The work purpose is to estimate a state of health on the basis of researches of functioning of the cores a life of providing systems of a children's organism and сliniсo-genetic features of children who were born at persons, irradiated in children's age; to develop the concept about a role genetic and environment factors in formation of a multifactorial pathology and to prove actions of its preventive maintenance. Methods of researches: clinical, laboratory, instrumental, statistical.Results and their novelty: The peculiarities of functioning of main life maintaining systems of an organism, thephysical development and a phenotype of children who were born from the parents who were irradiated at children's age were established. The tendency to an increase in the frequency of bronchial hyperreactivity, disorders of ventilating capacity and non respiratory functions of the lungs with the most expression in children - the inhabitants of 2-3 zones of radioactive contamination was noted. The indications of a decrease in the bioelectric activity and functional reserves of the muscular tissue were characteristic for children of this group. The decrease in adaptation-accomodation mechanisms, peculiarity of operative regulation of cardiac rhythm and dominating influence of parasympathetic nervous system under modelling the long functional loading was obtained in all groups. The changes in the hepatobiliary system were characterised by the high frequency of ехоsymptoms of dystonic and dyskinetic disorders of the biliary tract, the presence of deformations of the gallbladder in all groups of children. The higher frequency of an increase in the cross-section size of the liver was observed in children - inhabitants of radioactive polluted territories. A prevalence of the reactive changes and dismetabolic processes in the parenchyma of the pancreas in children of all groups observed was noted. The endoscopic semiotics of disorders in the gastroduadenal zone was characterised by a prevalence of a superficial inflammation, however in children of the ІІ basic group the wider spectrum of changes in the mucous membrane with increased frequency of disorders with atrophic, erosive, hemorrhagic and ulcerous character was noted. Unidirectional changes were marked in the children's immune status of the basic groups: a decrease in the relative quantity of CD3+56+-lymphocytes, imbalance of regulatory subpopulations, a decrease in Іg level and a decrease in the phagocyte number. In children with 137Сs activity indices in the body from 370 Бк to 2257 Бк the revealed disorders of ultrastructure of the blood cells were the most expressed from the side of energy forming structures. The phenotype of children in the basic groups differ by the increase frequency of morphogenetic variants with plural MAP, in which structure a visible place was occupied by MAP of the locomotors apparatus, and the constitution was more than in half of children characterised by disharmony, and by a delay in the biological age from the passport ones was accompanied in a considerable part of children from the ІІ group. The formation of multifactor pathology is under influence of the complex factors, among that the complicated heredity, the adverse micro-social environment, numerous medical and biologic risk factors in mother, some child's pathological conditions in the infantile period, certain features of early children's age are the leading ones. It was revealed the possible correlation bindings between dose thyroid loading of the mother, a dose of the general irradiation of parents and the development of immunodeficiency in children of the basic groups and increased frequency of bronchial hyperreactivity depending on 137Сs activity in the child body. The concept concerning a role of factors of an environment and genetic components in formation of a multifactorial pathology is proved. The system of the treatment-and-prophylactic actions directed on correction of infringements of a state of health of children which were born from the persons irradiated at children's age owing to Chernobyl accident is developed. Product Description popup.authors popup.nrat_date 2020-04-02 Close