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Information × Registration Number 0208U010219, 0107U001408 , R & D reports Title Study of possibility of application in medicine of naphthalimide and indoloquinoxaline derivatives as antivirals and interferon inducers popup.stage_title Head Andronati S.A., Registration Date 13-01-2009 Organization A.V.Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine popup.description2 We studied acute toxicity by intraperitonal introduction of naphthalimides and indoloquinoxalines - active antiviral agents and interferon inductors. It is set, that lypophicity increasing brings to enhacement of naphthalimides' acute toxicity and to decrease of indoloquinoxalines' one. Selected compounds show higher level of antiviral activity in ovo (in Gallinaceae embryos) against high pathogenous Sivash 2005 strain of influenza virus (H5N1). Effective technological schemes for synthesis of selected compounds are worked up and respective laboratory schedules are developed. Product Description popup.authors popup.nrat_date 2020-04-02 Close