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Information × Registration Number 0209U001524, 0107U010788 , R & D reports Title Development of catalysts on the basis of naturally occurring substances and their application for the synthesis of biologically active compounds popup.stage_title Head Kolodyazna O., Registration Date 06-02-2009 Organization Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Sciences of Ukraine popup.description2 As a result of the performed work it was found, that cinchona alkaloids and their modified derivatives catalyze the phosphor-aldol reaction of dialkylphosphites with carbonyl compounds, to afford optically active hydroxyphosphonates. The use of diastereomeric pairs of alkaloids allowed to obtain both optical antipodes of hydroxyphosphonates. It has been established, that single crystallization of enantiomerically enriched hydroxyphosphonates provides stereochemically pure stereoisomers. The hydrolysis of phosphonates leads to the formation of hydroxyphosphonic acids, and the reaction with DUST furnishes fluoroalkylphosphonates5635 Product Description popup.authors popup.nrat_date 2020-04-02 Close