Search academic texts

Information × Registration Number 0209U002564, 0106U003123 , R & D reports Title Investigation of mechanisms of epigenetic changes in the process of adaptation in the different age groups of animals popup.stage_title Head Bozhkov A.I., Registration Date 23-02-2009 Organization Kharkov national university named after V.N. Karazin popup.description2 Object of investigation - epigenetic changes.The investigations were carried out on Wistar rats age 3 and 21 month. The rats were divided on the groups with different diets and dietary habits. The intraperitoneal introduction of CuSO4 in dose 0,23 mg/g of liver were realized in every 48 hours to several groups. Work aim - investigation of reversible of the epigenetic changes under different influences.Methods of research - immunological and biochemical methods: determination of glucose-6-phosphatase activity, content of protein, and the influence the copper ions on. Young animals increased mass after adaptation diet a day. After 30 days the diet G-6-hosphatase activity increased in comparison with control and with animal which the copper sulfate was introducted.Specialized all-mash feed every day leaded to stunt and cocentration decreased of IgA and IgM of rats of the different age.Diets influence on the functional activity of the immune system, but diets, which limit the growth, it don't decriesof the ability to the adaptation of young and adult rats to such stress-factors as toxic metals. Product Description popup.authors popup.nrat_date 2020-04-02 Close