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Information × Registration Number 0209U002636, 0106U001584 , R & D reports Title Physiological, biochemical and structural-functional principles of cells adaptation to the effects of exogenous and endogenous factors popup.stage_title Head Bondarenko V.; Perskiy E., Registration Date 05-03-2009 Organization Kharkov National University named after V.N.Karazin popup.description2 Mechanical pressure influence on synthesis, processing and concentration of collagen, elastin and GAGs in the skin and aorta of rats, on visco-elastic properties of these organs, some intra- and internal sites of mechanical pressure signal transmission to the synthetic device of cells were researched.The synthetic intensity of investigated biopolymers was increased with the pressure growth, and after reaching the maximum, starts to decrease. The increase of the studied biopolymers synthesis intensity and concentration at physiological values of pressure; are adaptive cellular response to an external pressure. their decrease occurs at pressure that begin destroy the tissue structure, when synthetic possibilities of cells can be exhausted. The decrease in activity of oxidative deamination of lysine and oxylysine, of proline hydroxylase activity at mechanical pressure growth, took place . The degree of glycosylation of collagen at first increases, and having reached the maximum, decreases to the basal level.It is revealed, that protein-polysaccharide matrix formations represent an intercellular site of mechanical pressure signal transduction, and actin complex of the cytoskeleton.AlCl3 function in erythrocyte membrane stability at hypoosmotic conditions has been shown. Product Description popup.authors popup.nrat_date 2020-04-02 Close