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Information × Registration Number 0209U002697, 0106U001681 , R & D reports Title The study of immunomodulating effect mechanisms of low-molecular interferon inducers at persisting bacterial infections. popup.stage_title Head Ivanitsa Volodimir Oleksiovich, Registration Date 12-03-2009 Organization Odessa I.I.Mechnikov"s National University popup.description2 Тilorone decreases a death rate of mice, infected with Salmonella enteritidis, increases the lifetime of experimental animal and prevents the suppression of tissue macrophage functional activity. This drug decreases the number of Salmonella enteritidis cell, persistent in liver and spleen, however, it doesn't ensure complete salmonella elimination from organism. The cells of studied Salmonella enteritidis var. Isatchenko strain are sensitive to chloramphenicol, and this sensitivity is increased in the presence of interferon and tilorone. Combined application of tilorone with chloramphenicol speeds up the clearance of animal organism from salmonella and allows to halve the antibiotic dosage. Tilorone decreases manifestation of some Salmonella persistent characteristic. Occurrence of hypochromic effect in the tilorone spectrum in the presence of salmonella DNA indicates of its intercalation ability that can be considered as interferon inducer action mechanism at the molecular level. Product Description popup.authors popup.nrat_date 2020-04-02 Close