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Information × Registration Number 0209U005124, 0106U002360 , R & D reports Title To create the methodology of bronchopulmonary system clinical monitory of persons from the high risk of oncological pulmonary diseases in conditions of radionuclides influence of emergency and natural origin popup.stage_title Head Sushko V.A., Registration Date 16-01-2009 Organization State Institution "Research Center for Radiation Medicine of Academy of Medical Sciences of Ukraine" popup.description2 Object: retrospective estimation of lung cancer cases in the clean up workers of Chernobyl NPP accident, bronchopulmonary system of people, who underwent to radionucleads inhalation (n = 530): of the participants of liquidation of Chernobyl Catastrophe consequences (n=240), Object "Shelter" workers (n=170), Object "Shelter" personnel (170), inhabitants of the territories with high indoor radon 222 level (n=156). Aim: to provide diagnostic and prognostic measures, to create the methods for control of bronchopulmonary system state and find risk factors of oncopulmonological diseases. Methods: clinical, functional, X ray, endoscopy, immunological, screening (pulmonary screening), statistical. Case control study of 736 Chernobyl NPP accident clean up workers showed the tendency to dose relation of oncological pulmonary pathology in irradiation for 0,1 Gy in the conditions of possible radionucleades inhalation. The differences in activation status of alveolar macrophages and spectrum of cytokines were found. The formation of risk group for oncological pathology was started for the future prospective study. In COPD cases the combination of normal expression of EGFR, HER2 and tendency to high expression of Ki-67 were found. Methodology of clinical monitory of bronchopulmonary system state in people, who underwent to radionucleades inhalation was created. Product Description popup.authors popup.nrat_date 2020-04-02 Close