Search academic texts

Information × Registration Number 0209U005228, 0106U000598 , R & D reports Title To study cardiac remodeling pathogenical mechanisms in patients with arterial hypertension combined with 2 type of diabetes. popup.stage_title Head Koval S.N., Registration Date 27-01-2009 Organization State organization "Therapy Institute named after L.T. Malaya of Ukrainian Academy of Medical Sciences" popup.description2 The subject of the study: 311 patients with arterial hypertensiоn with and without 2 type diabetes mellitus. Methods: clinical, instrumental, biochemical. Statistically, development of hypertrophic type of heart remodeling, thickening of intima-media of total carotid arteries and manifestations of diastolic dysfunction of left ventricle are more frequently observed in patients with essential hypertension in combination with diabetes mellitus type 2 than in patients with essential hypertension and normal hydrocarbon exchange. It is found that in this type of patients, the processes of cardio-vascular remodeling are influenced not only by hemodynamic loading and metabolic changes but also by an increases of synthesis of insulin-like growth factor-1 (IGF-1) and transforming growth factor-В1 (TGF-В1). It is determined that the most unfavorable type of heart remodeling-concentric hypertrophia of left ventricle is characterized by a high level of malonic dialdegide, IGF-1 and TGF-В1, microalbuminuria in blood, while eccentric hypertrophia of left ventricle is accompanied by a noticeable decrease of IGF-1 levels. An effective adaptive therapy scheme is developed, which takes into account initial features of cardiovascular remodeling and levels of growth factors and uses perindopril with amlodipin or nebivolol. Product Description popup.authors popup.nrat_date 2020-04-02 Close