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Information × Registration Number 0209U005282, 0107U009267 , R & D reports Title Cytogenetical and phenotypical modifications tumor cells upon the long term exposition to interferon popup.stage_title Head Bezdenezhnykh Nataliya Oleksandrivna, Кандидат біологічних наук Registration Date 29-01-2009 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 In researching modifying influence of interferon on some phenotypic properties of human non-small-cell lung cancer cells upon prolonged exposition of the cells with interferon, it has shown that prolonged action of interferon results in significant and irreversible inhibition of manifestation of malignant phenotype: of proliferative potential and inhibited autonomy of the cells, in complicated cell ultrastructure and their shift to more differentiated phenotype, in increased expression of E-cadherin. Also, an inhibiting influence of interferon on expression of EGF receptors and VEGF in tumor cells have been shown, altered expression of drug resistance and apoptotic proteins. During modification cells by interferon were identificated changes of them sensitivity to cytotoxic factors and cytogenetic changes in population of tumor cells. This data show clonal reorganization population of tumor cells with prevelance of less malignant clones Product Description popup.authors popup.nrat_date 2020-04-02 Close