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Information × Registration Number 0209U005668, 0106U001522 , R & D reports Title Morpho-functional changes in different brain areas in aging and experimental brain injury and their correction by gene therapy popup.stage_title Head Kvitnitskaya-Ryzhova Tatiana Yurievna, Registration Date 11-03-2009 Organization State Institute of Gerontology of the Ukrainian Academy of Medical Sciences popup.description2 In traumatic brain injury (TBI), there occurred considerable destructive-dystrophic changes of neurons and gliocytes, being presented in old animals jointly with age-dependent changes. The use of gene therapy (plasmid AloE3) positively influenced the hippocampus structure and ultrastructure, i.e. reduced considerably the TBI-induced neuronal death, axonal lesion, gliosis and microglial reaction. Significantly, due to gene therapy the old injured rats have survived otherwise they died after several days following TBI. Product Description popup.authors popup.nrat_date 2020-04-02 Close