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Information × Registration Number 0209U008047, 0108U004232 , R & D reports Title Construction of stable high efficient strains of the yeast Candida famata capable for overproduction of riboflavin (vitamin B2); developing technology for production of the vitamin. Chapter 1. Construction of stable high efficient strains of the yeast Candida famata capable for overproduction of riboflavin (vitamin B2). popup.stage_title Head Sibirny Andriy Andriyovych, Registration Date 27-01-2009 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 Stable yeast strains of Candida famata able to riboflavin (vitamin B2) oversynthesis were obtained by integration of additional copy of gene SEF1 encoding positive regulator of riboflavin synthesis into the genome of previously constructed yeast strains. Medium composition and cultivation conditions were optimized to realize the maximal yield of target product. The laboratory model of technology of vitamin B2 production was developed on the base of constructed strains. As a result of this work two Ukrainian patents claimed useful model of yeast strains were released. Such strains could be used in industry as efficient producers of riboflavin (vitamin B2) due to increasing of their flavinogenic activity and stability of this trait. Two invention application claimed of the strains able to riboflavin oversynthesis were applied. Institute of cell biology NAS of Ukraine drew up an agreement with joint-stock company "Ladyghyn" (Vinnica region). In frame of such treaty, strains able to riboflavin oversynthesis were transferred to the "Ladyghyn", scaling of riboflavin producers cultivation as well as adjustment of industrial technology of production and purification of vitamin B2 were provided. Field of application - biotechnology. Product Description popup.authors popup.nrat_date 2020-04-02 Close