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Information × Registration Number 0209U008192, 0106U002106 , R & D reports Title Investigation of the reasons and mechanisms of endocrine dependent osteopathies in the young age; establishment of advisability of adaptogens application for their prevention popup.stage_title Head Sergienko L.Yu., Malova N.G., Registration Date 30-01-2009 Organization Ukrainian Research Institute of Endocrine Diseases Pharmacotherapy popup.description2 Object of study: rats-offspring of intact and stressed mothers during pregnancy. Aim of study: to determine the cause - consequence bond among pregnant stress and osteopathy development in young age of their offspring; to estimate the possibility of prevention of these pathologies by adaptogenes. Methods of study: pathophysiological, histological, immunoenzymatical, statistical. Вeing stressed in the 1st trimester of pregnancy female rats developed phetoplacental insufficiency resulted in an increased stress-induced destructive processes in the bone tissue of their offspring. Along with antistressful properties adaptogenic preparations "Gerimax" and Adaptol" have certain positive osteo-stimulating effect for preventing stress-induced osteopathies developments. It this context, the above preparations are advisable to go through further clinical trials on prophylaxis and treatment for osteopathies and osteoporosis. Based upon the certain results from examining the bone tissue of females' offspring treated with "Kardonat" a primary osteopathy prophylactic method for at-risk-patients has been determined. Sphere of application: endocrinology, neonatology, pediatry, family medicine, osteology. Product Description popup.authors popup.nrat_date 2020-04-02 Close