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Information × Registration Number 0209U008193, 0106U002107 , R & D reports Title Оptimization of diagnostics and treatment of thyroid nodular euthyroid pathology popup.stage_title Head Karachentsev Juriy Ivanovich, Доктор медичних наук Registration Date 30-01-2009 Organization Ukrainian Research Institute of Endocrine Diseases Pharmacotherapy popup.description2 Research object:the patients with the nodular untoxic goiter and thyroid cancer (TC). Purpose of work: determination of risk degree of thyroid malignisation on the basis of exposure of nosotropic features of nodular thyroid pathology.The methods of research: common clinical investigations, thyroid ultrasound examination, histological, immunehisochemical methods of research of thyroid gland with the different forms of nodular pathology, methods of formal genetics, statistical. The analysis of interferences is conducted for the uninodular goiter and TC for period 1985 - 2005. It is certain that growth of middle ages is a factor, that is instrumental in growth of prevalence of TC. Mutation to the Т1796А gene of BRAF was found in 27,3 % of tumor patients with a papillar TC and did not meet sight other UNG and malignant thyroid pathology. It is discovered that thyroid ultrasound examination for diagnostics of malignant pathology has a low value except for the presence of knots of wrong form with unclear unequal contours.Appearance of IV type collagen, the increase of expression of receptors to the endothelin-1 by the vascular endotheliocytes, the growth of T-killers activity on a background a deficit of IL-2 products and oppressing of helpers and suppressors functions in the local immuno- reactions can be used as diagnostic criterion of thyroid malignisation. Markers and an algorithm are set for immunehisochemical differential diagnostics of thyroid new formations on the basis of CK7, CK20, СК34вЕ12 and Galectin-3 expression. The method of urgent intraoperational histological research of the frozen cuts, that allowed to improve interpretation of thyroid material. Branches of application: medicine, surgery, endocrinology. Product Description popup.authors popup.nrat_date 2020-04-02 Close