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Information × Registration Number 0209U008194, 0106U002108 , R & D reports Title Development of diagnostic, prophylactic and treatment complex for diffuse toxic goitre popup.stage_title Head Karachentsev J.I., Povoroznuk V.V., Registration Date 30-01-2009 Organization Ukrainian Research Institute of Endocrine Diseases Pharmacotherapy popup.description2 Object of study: the state of Wistar rats bone tissue in experimental exogenic hyperthyroiditis depended upon age, sex and the function of sexual glands. Diffusal toxic goiter (DTG) - afflicted patients (rats). Goal of study: examining risk-factors, structural and functional peculiarities in the bone tissue of DTG-affected (patients) rats. Developing particular approaches in diagnostics, prophylaxis and treatment. Methods: clinical, ultrasonic, immune fermental, biochemical, x-ray methods. The gender and agedependent features of changes were studied on bone mineral density (BMD) for white rats are exposed to high doses of thyroid hormones and for a long term after termination of. For the first time, the polyetiologe models of the second osteoporosis. The efficiency of treatment of the second osteoporosis on the model of experimental hyperthyroidism depending on age and gender was studied. It was proved, that the roentgen morphometry analysis and ultrasonic densitometry expose osteoporosis at 75 - 97 %patients with DTG. It grounds the necessity of taking of patients with DTG to the risk group of osteoporosis and requires timely dispauserisation and medicinal treatment health. Clinical approbation of the method of second osteoporosis treatment at the patients with DTG by the complex of "Calcimine advance" and "Miacalcic" proved their high efficiency. Treatment allows to stop the losses of mineral closeness of bone tissue and stimulates the increase of mass of bone tissue, normalizes the processes of bone remodeling, diminishes a pain syndrome, promotes motive activity, improves the quality of patient life. Product Description popup.authors popup.nrat_date 2020-04-02 Close