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Information × Registration Number 0209U008322, 0108U005628 , R & D reports Title Study of the existing anti-retroviruses drugs influence on the separate parts of cell metabolism popup.stage_title Head Veliky M.M., Registration Date 26-02-2009 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 Azidothymidine (zidovudine), the first nucleoside analogue of reverse transcriptase inhibitor approved for treatment of HIV infection, caused an increase in the apoptotic cell death of rat thymocytes. Alpha-tocopherol, thioproline and formate treatment decreased toxic effects of azidothymidine and increased the thymocytes survival as determined by MTT analysis. The protective effect of alpha-tocopherol on azidothymidine-induced apoptosis of rat thymocytes could be explained by its ability to prevent mitochondrial dysfunction. Product Description popup.authors popup.nrat_date 2020-04-02 Close