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Information × Registration Number 0209U008336, 0106U002599 , R & D reports Title Study of processes which happen at apoptosis, induced by antineoplastic drugs with different mechanisms of action popup.stage_title Head Stoyka Rostyslav Stepanovych, Registration Date 26-02-2009 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 Glycosyl determinants of cells induced to apoptosis by various agents, and of perypheric blood lymphocytes of autoimmune patients were characterized. New method of cytochemical detection of membrane neuraminidases was developed and applied for studying the role of these enzymes in changes of membrane glycoprotein pattern in the apoptotic cells. The effect of anticancer drug doxorubicine on the transforming growth factor beta 1-induced translocation of signaling proteins Smad-2 and Smad-3 to the nucleus of human lung adenocarcinoa cells of А549 line was defined. The role of mitochondria in realization of differential cytotoxic effect of various alkaloids was evaluated. Application of murine NK/Ly lymphoma for studying mechanisms of action of different anticancer drugs in vivo allowed characterization of their signaling mechanisms towards cell proliferation and apoptosis during development of that tumor. Mechanisms of antineoplastic action in vitro of novel antibiotic landomycin E were characterized. Itwas capable of suppessing growth and survival of tumor cells possessing various mechanism of resistance to well known anticancer drugs. It was firstly found that immunoglobulins purified by the affinity chromatography from blood plasma of a significant part of lupus erymatosus patients were capable of hydrolyzing histone H1. Product Description popup.authors popup.nrat_date 2020-04-02 Close