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Information × Registration Number 0209U008785, 0107U001191 , R & D reports Title The investigation of immune system antitumor link disturbanсes in malignat brain tumors and its correction by biologic and immunomodulating factors popup.stage_title Head Lisyaniy Nicolay, Registration Date 18-12-2009 Organization SI "Institute of Neurosurgery named after acad. A.Romodanov, AMS of Ukraine" popup.description2 The object of the investigation - immunocompetention cells, tumor cells and blood serum. The aim is to determine the main violations in the system of antitumor immune defense in the presents of malignant brain tumors and medduloblastoma and to create the ways of their correction in vivo and in vitro.Methods - immunological, pathomorphological and experimental. To determine different cytotoxic activity of auto and allolymphocyte in case of glioma's cells in according to anaplasia's degree and possibility of raising lectins of mistletoe and peanut of cytotoxic activity of lymphocytes of neurooncology patients. To discover different level of fixed and circulated antibodies to autoantigenes of these tumors that depends on histologic peculiarity of tumors. To show antigens differences between tumors of different level of anaplasia. In vitro determines cytotoxic action of peptides of embryo 's neural tissue, humoral factors of embryo's brain and liver on brain tumor cells and determines immunoregulation action of peptides of embryo's brain on mononuclears of neurooncology patients. During research we received a lengthening of rats' life with experimental glioma during intraperitoneal injection of humoral factors of embryo's neurocells of rats and peptides of embryo's brain of rats. Comparatively study a growth of glioma and a duration of life of experimental animals during the medical treatment by lectins of heanut and mistletoe, UKRAIN and immunomodulator GALAVIT. To discover the most perspective using of GALAVIT and UKRAIN in clinical practice.Field of use - neurosurgery. Product Description popup.authors Бєльська Людмила Миколаївна Бутрім Олександр Іванович Гнєдкова Ірина Олександрівна Данчук Сергій Вікторович Ключнікова Антоніна Іванівна Лісяний Микола Іванович Лісяний Олександр Миколайович Любич Лариса Дмитрівна Мазніченко Оксана Леонідівна Маркова Ольга Володимирівна Носов Анатолій Тимофійовіч Орлов Юрій Олександрович Потапова Антоніна Гнатовна Розуменко Володимир Давидович Семенова Віра Михайлівна Стайно Лариса Петрівна Шмельова Анна Анатоліївна popup.nrat_date 2020-04-02 Close