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Registration Number

0209U010269, 0109U007541 , R & D reports

Title

The study of influence of phytomelanine on structural and functional state of gastric mucosa in conditions of long-term hypergastrinemia evoked by omeprazole

Head

Tsyryuk Olena Ivanivna,

Registration Date

26-10-2009

Organization

Taras Shevchenko Kiev university

Description

Studies were conducted on Westar white rats. The animals were divided into two groups. In the first group investigated the effect of melanin on the basal gastric secretion in conditions of prolonged hyperhastrinemy, induced by 28-day administration of omeprazole. In the second group was examined the influence of melanin on the morphological state of gastric mucosa after prolonged hyperhastrinemy. As a result, studies found that melanin are effectively protects the gastric mucosa transformations, evoked by long-term administration of proton pump inhibitors.

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Берегова Тетяна Володимирівна
Цирюк Олена Іванівна