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Information × Registration Number 0209U010521, 0105U008878 , R & D reports Title Complex experimental study of the pharmacological activity of new derivatives of germanium containing compounds with bioligands popup.stage_title Head Kresyun V O, Registration Date 15-12-2009 Organization Odessa state medical university popup.description2 For the first time it was established the action of new oxyethylendiphosphonates on behaviour activity of intact animals and during experimental neuropathologic syndroms. Studied compounds, depending on their chemical structure, possess tranquilizing, adaptative, anticonvulsant and others neurotropic effects. Germamid has the most expressed anticonvulsant action: the mechanism of germamid's action is established. At different experimental models of parkinsonic syndrome the efficiency of germacord is set. On a background of the toxic damage of liver a hepatoprotective action of new compounds is revealed. In addition, the mechanism of action of new compounds has been studied. According to force of membranoprotective effect new compounds are disposed as following: nicogerm > germamid > germacord. Advantage. The neurotropic and hepatoprotective effects of new biological active compounds from the oxyethylendiphosphonate derivatives are first explored. For the first time it was established mechanisms of action of the most active compounds. . Product Description popup.authors popup.nrat_date 2020-04-02 Close