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Registration Number

0209U010550, 0105U008884 , R & D reports

Title

The Patogenetic foundation of the pathes of the reparation postray disorders of the reproductive health in experiment

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Head

Mardahco Alexsey Alexseevich,

Registration Date

15-12-2009

Organization

Odessa state medical university

Description

Irradiation of adult animals leads dose-dependant decreasing of the content of amino acids as a precursos of creatine syntehesis the liver and kidney, decreasing of guanidyn-acetate methylation. As a result decreasing of creatine and creatinine content in muscles and activity of creatine kinase because of CC-MM and mitochondrial forms were obtaihed. Firstly it was shown that decreasing of animals radio resistance takes place on the back of the dose-dependant decreasing of the content of amino acids-precursors of creatine synthesis in liver and kidney, decreasing of guanidyn-acetate methylation and of creatine kinase activity because of CC-MM and mitochondrial forms of enzyme. The pathogenetic ways of the obtained disturbances correction were proved. The use of them improves the reproductive health of irradiated animals.

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Будаленко Ольга Іванівна
Васильєва Антоніна Георгіївна
Дімова Ала Анатоліївна
Кузьміна Ала Володимирівна
Мардашко Олексій Олексійович
Мохамед Амін Шафук
Ратушненко
Сідельникова Тетяна Андрієвна
Степанов Геннадій Федорович
Сторчило Ольга Вячеславівна
Халиль Джарад
Ясиненко Ніна Євгенівна