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Information × Registration Number 0209U010559, 0107U011173 , R & D reports Title Optimization of diagnostic and treatment modalities in woman with pathology of reproductive system with identification of pathogenetic molecular-genetic mechanisms. popup.stage_title Head Zaporozhan Valeriy, Registration Date 15-12-2009 Organization Odessa state medical university popup.description2 Developed algorithm of prediction and prevention of pelvic adhesions amongst patients after endosurgery of leiomyoma uteri and external genital endometriosis by the analysis of NAT activity and rate of IL4, IL6, IL10 and IL12 at the preoperative stage allows determining the risk group for pelvic adhesions. The maximal risk of pelvic adhesions (RR=2,4 (1,8;2,9) is characteristic for the patients with the high rate of NAT activity (more than 30 ?M per minure mg of substrate), when IL-6 more than 16,7 ng/ml (reference values 5,6 ±0,1 ng/ml) and IL-10 - more than 24,8 ng/ml (reference value 7,8±0,2 ng/ml). Isolated use of the indices of NAT activity and cytokines rates is not informative for prediction of pelvic adhesions. If these indices are accounted simultaneously than the diagnostic test values is increased significantly (p<0.05) for assessment of adhesion risk. There was developed the program of complex prevention which improved treatment outcomes, i.e. pain syndrome was decreased in 1.8 folds, the frequency of adhesion relapses was diminished by 20% by the data of second-look laparoscopy. Product Description popup.authors Александров Олексій Леонідович Волянська Алла Георгіївна Гладчук Ігор Зіновійович Желєзов Дмитро Миколайович Запорожан Валерій Миколайович Латій Кирило Володимирович Мищенко Валентина Павлівна Рожковська Наталя Миколаївна Стрельник Олена Ігорівна popup.nrat_date 2020-04-02 Close