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Information × Registration Number 0210U000140, 0104U012451 , R & D reports Title To define the pharmacogenetics features of application beta-adrenoblockers in patients with chronic heart failure and to develop the differentiated pharmacotherapy of disease. popup.stage_title Head Yr. S. Rudyk, Registration Date 22-01-2010 Organization State organization "Therapy Institute named after L.T. Malaya of Ukrainian Academy of Medical Sciences" popup.description2 The 195 patients with chronic heart failure (CHF) (NYHA I-IV). The methods are clinically, genetic-biochemistry, instrumental. Detected, the prevalence of different types of a gene polymorphism of beta1-adrenoreceptors and there gaplotypes in patients with CHF. Estimated, the relationship of gene polymorphism with morph-functional parameters of a heart. The beta-blockers have the most positive influence in patients with Ser49Ser/Arg389Arg gaplotype of the gene of beta1-adrenoreceptors. They are less effect in patient with Gly389Gly polymorphism. Product Description popup.authors Алексєєва М.О. Бондаренко Т.І. Кравченко І.Г. Лозик Т.В. Мухіна О.К. Педан Н.В. Пивовар С.М. Рудик Ю.С. Удовиченко М.М. popup.nrat_date 2020-04-02 Close
R & D report
To define the pharmacogenetics features of application beta-adrenoblockers in patients with chronic heart failure and to develop the differentiated pharmacotherapy of disease.
Head: Yr. S. Rudyk. To define the pharmacogenetics features of application beta-adrenoblockers in patients with chronic heart failure and to develop the differentiated pharmacotherapy of disease.. (popup.stage: ). State organization "Therapy Institute named after L.T. Malaya of Ukrainian Academy of Medical Sciences". № 0210U000140
1 documents found

Updated: 2026-03-23


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