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Information × Registration Number 0210U000406, 0107U000615 , R & D reports Title Experimental study of the role of cellular calcium ions in programming of neuroendocrine pathology resulted from disturbances of epigenetic control of individual development popup.stage_title Head Reznikov Olexandr Grygorovych, Registration Date 12-02-2010 Organization State Institution "V.P. Komisarenko Institute of Endocrinology and Metabolism оf the Academy of Medical Scienses of Ukraine" popup.description2 Object of investigation. Neuroendocrine regulation of systems of reproduction and adaptation. Aim of investigation. To elucidate the role of intracellular calcium ions in pathogenesis of neuroendocrine disorders of reproduction and adaptation resulted from hormonal imbalance and stress during perinatal period of the individual development. Methods. Physiological, biochemical, hormonal, statistical. Results. The modulating effects of calcium channel blockers verapamil and nimodipine used in perinatal period on the process of brain sexual differentiation and reproductive and adaptive functions were revealed. Perinatal application of the mentioned preparations prevented induced by hormonal imbalance changes of protein profile in discrete brain structures in rats as well as stress and noradrenergic reactivity of HPA axis, while disorders in brain androgen metabolism and sexual cyclicity and sexual behavior were not affected. Results obtained suggest the participation of calcium signalling in forming of neuroendocrine regulation of reproductive and adaptive systems in early ontogenesis and in pathogenesis of its epigenetic disorders resulted from hormonal imbalance and stress. Degree of introduction. Scientific article and reports. Sphere of application. Endocrinology, pathophysiology. Product Description popup.authors Лимарєва А.А. Носенко Н.Д. Резніков О.Г. Сініцин П.В. Тарасенко Л.В. popup.nrat_date 2020-04-02 Close