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Information × Registration Number 0210U000699, 0105U002470 , R & D reports Title Significance of haemodynamic and humoral mechanisms of chronic heart failure development, and atrial fibrillation, in elder patients with artery coronary disease, arterial hypertension and chronic congestive disease of lungs, and treatment by angiotensin-converting enzyme inhibitors and blockators of beta-adrenergic receptors. popup.stage_title Head Pristypa Lydmila, Registration Date 11-03-2010 Organization Sumy State University popup.description2 The work is devoted to the study of systolic and diastolic function of left ventricle, cytokines, metabolism of lipids and glucose, their connection in development and progressing of chronic heart failure in patients with metabolic syndrome, and effectiveness of ACE-inhibitors and statins. It fixed, that high levels of cholesterol and triglycerides in patient with type ІІ diabetes are more than in patients with abnormal glucose tolerance. Diastolic dysfunction of left ventricle (abnormal relaxation and "pseudonormal" type) is frequent type of development of chronic heart failure in patients with metabolic syndrome. The connection of cytokines levels (TNF, IL-1, IL-8) and functional class of chronic heart failure is the typical characteristic for patients with metabolic syndrome. There is inverse correlation between eject fraction and TNF level in patient with metabolic syndrome and type ІІ diabetes. Influence of ACE-inhibitors (enalapril, lisinopril) and statins (lovastatin) resulted in decrease cytokines' level (TNF, IL-1, IL-8). This treatment improved function of left ventricle and indexes of lipid metabolism in patients with chronic heart failure and metabolic syndrome. Product Description popup.authors Деміхова Надія Володимирівна Кириченко Н.М Лаба В.В Мохамед Хасан Мохамед Сід Ахмед Приступа Л.Н Псарьова В.Г Руденко Т.М popup.nrat_date 2020-04-02 Close