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Information × Registration Number 0210U000899, 0109U003366 , R & D reports Title Investigation of molecular and genetic mechanisms of hypoxic preconditioning, and elaboration of methods for phenotypic cardioprotection under high altitude hypoxia influence popup.stage_title Head Portnychenko Alla Georgiyivna, Registration Date 08-04-2010 Organization International Center Astronomical, Medical and Ecological Research popup.description2 Molecular and genetic mechanisms induced under influence of different regimen of high altitude hypoxia require of detail investigation for their purposeful using to prevent heavy cardiovascular pathology. The changes of gene expression were investigated in rats influenced by high altitude hypoxia and hypoxical preconditioning on Elbrus station of ICAMER NASU. It was shown that high altitude hypoxia prevents age reduction of transcription factor HIF-1alpha in myocardium, activates compensatory HIF-3alpha - dependent mechanisms. Purposeful induction of genes by hypoxical preconditioning led to activation IGF-1- and HSP60-mediated mechanisms of prolonged reprogramming of energy metabolism in cardiomyocytes without dangerous activation of proliferative processes. The method for hypoxical preconditioning on high altitude has been carried out, which demonstrated prolonged favorable influence on cholesterol and its fraction content in blood of volunteers, water and electrolyte balance, metabolic processes. Elaborated method is perspective for clinical investigation and introduction into clinical, sports and professional medicine. Product Description popup.authors Василенко Марина Ігорівна Древицька Тетяна Ігорівна Портніченко Володимир Ілліч Портниченко Алла Георгіївна Сидоренко Алла Михайлівна Сурова Ольга Василівна popup.nrat_date 2020-04-02 Close