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Information × Registration Number 0210U000912, 0107U005334 , R & D reports Title Investigations of mechanisms protection of myocardium induced by of the new domestic fluorine-containing openers of ATP-sensitive potassium channels popup.stage_title Head Moybenko Olexij Olexijovych, Registration Date 09-04-2010 Organization Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 In accordance with the task of present scientific-research work influence of new domestic fluorine-containing opener of ATP-sensitive potassium channels was investigational on the function of mitochondria, system NO, free-radical processes, apoptosis, content of arachidonic acid and her derivatives (LTC4 and TxB2) in arterial blood at ischemia-reperfusion of myocardium and in a norm. It is shown that new activators change the processes of the oxidizing phosphorylating in mitochondria, oppress an apoptosis, had the antioxidant properties, reduced free radical production, reduced formation of leukotrienes and thromboxanes. It has shown that under modeling experimental acute ischemia-reperfusion flokalin reduced activity iNOS and increase activity cNOS. Product Description popup.authors А.М. Шиш О.О. Мойбенко Р.А. Ровенець Р.Б. Струтинський popup.nrat_date 2020-04-02 Close
R & D report
Investigations of mechanisms protection of myocardium induced by of the new domestic fluorine-containing openers of ATP-sensitive potassium channels
Head: Moybenko Olexij Olexijovych. Investigations of mechanisms protection of myocardium induced by of the new domestic fluorine-containing openers of ATP-sensitive potassium channels. (popup.stage: ). Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine. № 0210U000912
1 documents found

Updated: 2026-03-26


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