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Information × Registration Number 0210U000966, 0107U007191 , R & D reports Title The use of bioactive lipid, N-stearoylethanolamine, as a remedy for increase the efficacy and for decrease the level of the side effect of antitumor medicine popup.stage_title Head Gula Nadiya Maxymivna, Registration Date 26-04-2010 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 Taking into consideration the ability of N-stearoylethanolamine (NSE) to inhibit tumor growth and its membraneprotective, antioxidative and antiinflammatory activities the goal of our work is to study protective effects of NAE regarding cell and tissue homeostasis of animals with tumor under antitumor chemotherapy with cytotoxic agent. It was shown that NSE, being used as antitumor agent has individual ability to inhibit growth of main tumor node. But being used in complex therapy with cysplatin it has no influence on cytostatic activities of cysplatin. At the same time (in complex therapy with NSE) we observed urea and creatinine levels decrease in blood of animals; also it was shown that in kidneys of animals with tumors NSE (against a background of cysplatin chemotherapy) prevents phosphatidylcholine lysoforms accumulation as well as accumulation of lipids peroxidation products - which points on decrease of toxic effects of cysplatin on relatively normal tissues of animals with tumor. Our findings are pointing out on opportunity to use NSE in a complex therapy with cysplatin in order to improve general state of oncologic patient at the time of medical Product Description popup.authors Асмолкова В.С Бердишев А.Г. Глухова В.М. Горідько Т.М. Гудзь Є.А. Клімашевський В.М. Косякова Г.В. Тодор І.М. Хмель Т.О popup.nrat_date 2020-04-02 Close