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Information × Registration Number 0210U000969, 0107U008673 , R & D reports Title Targeted modification of signalling pathways involved in the control of cell apoptosis using С60 и С60 -composites and investigation of biological activity of nano-sized iron-oxygen compounds in free-radical processes popup.stage_title Head Donchenko Georhij Victorovich, Drobot Liudmyla Borysivna, Registration Date 26-04-2010 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 The obtained experimental results demonstrate biological activity of the studied nanosized iron-oxygen structures of feryhidryte HF and goethite -FeOOH. Their effect on the activity of the cells antioxidant enzymes, lipid peroxidation in vitro were determined. Based on the experimental data obtained we conclude that the investigated nanosized iron-oxygen structures of feryhidryte HF as well as goethite -FeOOH leads to oxidative stress. Proposals has made for further studies of nanoscale iron-oxygen structures in medicine, particularly oncology to prevent the growth of malignant tumor cells.The selective protective action of fullerenes С60 on normal but not malignant T cells, as well as selective cytotoxic action of photoexited fullerenes on malignant but not normal T cells was revealed. The obtained data make it possible to consider fullerenes С60 as perspective objects for the development of complex approaches in lymphomas therapy. Product Description popup.authors Биць Надія Вікторовна Донченко Георгій Вікторович Дробот Людмила Борисівна Дубовецький Артем Сергійович Кузьменко Олександр Іванович Марченко Світлана Миколаївна Матишевська Ольга Павлівна Паливода Ксенія Олегівна Паливода Ольга Михайлівна Самойленко Анатолій Анатолійович Філіпович Володимир Павлович popup.nrat_date 2020-04-02 Close