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Information × Registration Number 0210U000972, 0107U007201 , R & D reports Title The creation of antithrombotic compounds, which block fibrin polymerization sites popup.stage_title Head Komisarenko Serhiy Vasyliovych, Доктор біологічних наук Registration Date 26-04-2010 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 It has been established that 5,11,17,23-tetrakis[bіs(dihydroxyphosphoryl) methyl] calix[4]arene (C-192) and its sodium salt (C-145) are the strong inhibitors of fibrin polymerization and formation of three-dimensional fibrin net which are the framework of the thrombus. The IC50 values of calixarenes C-192 and C-145 were 0,5 10-6 М and 2,5 10-6 М respectively. These low molecular weight organic compounds may serve the basis for the design of antithrombotic preparations. It has been established that synthetic peptide, which corresponds to fibrin fragment B 19-26, specifically inhibits fibrin formation in fibrinogen+thrombin system. Product Description popup.authors Гоголінська Генрієта Казимірівна Гриценко Павло Григорович Колесникова Ірина Миколаївна Комісаренко Сергій Васильович Костюченко Олена Петрівна КошельТетяна Анатоліївна Литвинова Людмила Михайлівна Луговська Наталія Едуардівна ЛуговськойЕдуард Віталійович popup.nrat_date 2020-04-02 Close