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Information × Registration Number 0210U001131, 0107U000922 , R & D reports Title Efficacy estimation of curative-prophylactic tools directed on correction of clinical/metabolic manifestations of syndromes of leptinresistance and insulinresistance in ChNPP accident survivors, their descendants, with application in healthcare practice popup.stage_title Head Kovalenko A.N., Registration Date 25-01-2010 Organization Research Centre for Radiation Medicine popup.description2 Study subject: the ChNPP accident survivors i.e. emergency and recovery workers of the year 1986 period both with contaminated territory residents suffering leptinresistance and insulinresistance syndromes aged 14-45 years at the time of accident (313 persons), children born in 1987-1993 (212 persons). Total number of the study subjects was 525. Study objective: assessment of the efficacy of therapeutic and prophylactic remedies in metabolic disorders correction under leptinresistance and insulinresistance syndromes among the ChNPP accident survivors, and implementation in the healthcare practice. Study methods: clinical, anthropometric, biochemical, hormonal, instrumental, and statistical. It was revealed that IR and/or IR syndromes occur in ChNPP accident survivors in case of a less severe body mass excess than in general population. Administration of biguadnide preparation Metfogamma, sulfonurea Amaryl and thiazolidinedione Pioz is effective as hypoglycemic monotherapy in case of initial and mild forms of disease. Pioz and Metfogamma intake is followed by insulinresistance reduction. In case of ineffective oral hypoglycemic remedies the insulin therapy is absolutely indicated. Basis-bolus therapy with insulin analogues and insulin combination with sulfonurea is more effective that human insulin preparations in correction of carbohydrate metabolic disorders in diabetic patients having leptinresistance and insulinresistance syndromes. Serum triglyceride content lowering by means of fibrates administration restores physiological action of leptin, tends to food behavior normalization with leptinresistance decrease in diabetic type 2 patients having body mass excess. Puberty period is critical for insulinresistance initiation in adolescents and young adults. Complex program has been introduced for body mass decrease, being the set of tools for food consumption decrease, lowering of nutrients absorption, bowel peristalsis acceleration, amplification of energetic fission of proteins fats and carbohydrates leading to body mass decrease in children born from parents survived after the ChNPP. Product Description popup.authors Єгорова Ірина Вікторівна Афанасьєв Дмитро Євгенович Бєлий Давид Олександривич Ваколюк Катерина Олександрівна Верескун Сергій Борисович Грищенко Катерина Володимирівна Запісочний Олексій Захарович Камінський Олексій Валентинович Копилова Ольга Василівна Муравйова Ірина Миколаїна Рожківська Любов Володитирівна Самойлов Олександр Олександрович Теплпа Олена Валеріївна Чикалова Ірина Григорівна popup.nrat_date 2020-04-02 Close