Search academic texts

Information × Registration Number 0210U001586, 0106U005546 , R & D reports Title The approaches of foundamental grounds to the cancer vaccines construction on the base of fetal tissues popup.stage_title Head Potebnya Grygoriy Platonovych, Registration Date 26-02-2010 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 The protein fractions from embryo tissues of different origin were extracted and purified; their immunological features were investigated. There were conducted experiments dealing with anticancer and immunomodulating properties of the extracted xenogenic proteins. The anticancer vaccine was made from chicken embryo proteins of early gestation period (7-th day) and proteins with molecular weights of 18.5 and 70 kDa which are produced by B.subtilis B-7025. It was shown that the vaccine can induce anticancer immune response and statistically significantly suppress growth of Lewis lung carcinoma tumour and metastases. According to the experiments, such a xenogenic anticancer vaccine is most effective after surgical resection of primary tumour. The results of investigations indicate that chicken embryo proteins can be used as a "universal" immunogen in the making of xenogenic anticancer vaccine to be applied for treating cancer of different localization. Product Description popup.authors Євстратьєва Людмила Миколаївна Базась Володимир Миколайович Воєйкова Ірина Михайлівна Діденко Геннадій Василович Дідківська Лідія Павлівна Караман Ольга Михайлівна Коханівська Любов Миколаївна Кузьменко Олександр Петрович Лісовенко Володимир Григорович Лісовенко Галина Степанівна Русанова Людмила Іванівна Симчич Тетяна Василівна Тітова Галина Пантеліївна Танасієнко Ольга Андріївна Федосова Наталія Іванівна Хмара Валерій Антонович Черемшенко Надія Леонідівна Шпак Євген Григорович Юдіна Ольга Юріївна popup.nrat_date 2020-04-02 Close