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Information × Registration Number 0210U001587, 0107U004941 , R & D reports Title Investigation of properties for molecular genetic markers underlying the diagnostics of oncological pathology popup.stage_title Head Rynditch Alla Volodymyrivna, Доктор біологічних наук Registration Date 26-02-2010 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 Comparison of SAGE and microarray analysis data revealed 117 genes which can be used for molecular typing of glioblastomas. Results of the comparison were confirmed by Northern hybridization and RT-PCR of surgical samples of glial tumors. Downregulated in glioblastoma genes(CPNE6, GALNT9, SLC1A6, GRM4, FSTL5, FAT2, NEUROD1) are most probable tumor suppressor gene candidates. Increasing of proliferative potential of the cells with overexpressed CHI3L1 genesuggest about potential oncogenic properties of YKL-40 protein encoding by this gene. Analysis of the expression of eEF1A1, eEF1A2, eEF1B , eEF1B and eEF1B genes, encoding different subunits of elongation factor 1, in glial tumors suggest about potential involvement of eEF1B subunits in tumorogenesis. Analysis of the methylation profiles of CpG-islands of promoter regions of chromosome 3 genes in epithelial tumors revealed about 30 new potential marker genes for their diagnosis. Product Description popup.authors Дмитренко Володимир Володимирович Кавсан Вадим Мусійович Негруцький Борис Сергійович Філоненко Валерій Вікторович Циба Людмила Олексіївна popup.nrat_date 2020-04-02 Close