Search academic texts

Information × Registration Number 0210U001693, 0107U005540 , R & D reports Title The use of 5-aminolevulinic acid for photodinamic purging of bone marrow autotransplants from leukemic cells: the generation of new technology and its testing with animal bone marrow and material from leukemic patients popup.stage_title Head Gamaleia Nikolay Fedorovich, Registration Date 19-03-2010 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 The method of ALA-mediated photodynamic purging of hemopoietic cells from residual leukemia cells was tested on the mononuclear leukocyte fraction, obtained from patients with hemablastoses. Investigations of the material from such patients showed that the number of CD34+ stem cells, which can be isolated from the mononuclonal leukocyte fraction, depends on the patient's diagnosis (common type acute lymphoblastic leukemia, different stages of acute myeloblastic leukemia, and so on). The responsiveness of CD34+ cells from leukemia patient's blood to the ALA-mediated photodynamic treatment is bound up with an immunophenotype of the cells which determines if the CD34+ stem cell is hemopoietic or leukemic. Product Description popup.authors Гамалея Микола Федорович Шишко Євгенія Денисівна popup.nrat_date 2020-04-02 Close