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Information × Registration Number 0210U001862, 0106U010931 , R & D reports Title Search the correction's methods of synaptic plasticity changing on different levels of nervous system under experimental pathology. popup.stage_title Head Kostiuk Platon G., Registration Date 22-04-2010 Organization International center of molecular physiology popup.description2 Performed project was aimed to finding the synaptic transmission correction arising from pathological conditions of the nervous system (diabetic neuropathy, etc.) that can be used to facilitate neyropatic syndromes. During carrying out the project the specific blockers of different types of calcium channels in the modulation of pain signals transferring from primary to secondary nociceptive neurons were studied . Blockers of high-and low-threshold calcium channels as well as the blockers of TRP cflcium channels were applied. In experiments conducted on nociceptive DRG neurons it was found that potential-operated calcium channels, TRPV-channels and also the interaction of these structures were involved in the creation of signals and neurogenic pain syndromes. Particular changes that occur in different forms of neuropathy - heat hypoalgesia and thermal hyperalgesia also have been described. In the course of the project were also obtained the results concerning for the model system of synaptic transmission of neurons - chromaffin cells of the adrenal gland. The role of TRP-channels in calcium signaling and release of neurotransmitters in the process of exocytosis was investigated on this subject. Fulfilled project is very important and represents a substantial interest for specialists in neurophysiology, physiology, biophysics and medicine. Product Description popup.authors Войтенко Н.В. Костюк О.П. Лукянець О.О. popup.nrat_date 2020-04-02 Close