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Information × Registration Number 0210U001863, 0106U010932 , R & D reports Title Electrical activity and intracellular Ca correlation of single retina cell's at normal and pathology popup.stage_title Head Fedulova Svitlana A., Registration Date 22-04-2010 Organization International center of molecular physiology popup.description2 The role of Kv3 potassium channels in the fast tonic firing pattern generation of rat RGCs was established on rat isolated retinal preparation by using of voltage/current clamp technique in whole cell mode. In the first time on retinal preparation firing-induced calcium signals were recorded and their characteristics were determined. It was shown that Kv3 channels prevent the cells from calcium overload during high frequency action potential firing. Voltage-activated calcium currents and intracellular calcium concentration changes caused by their activation were recorded, characteristics of appropriate calcium signals were determined. The data obtained gave theoretical base for development of new approach in normotensive open-angle glaucoma treatment. In clinical researches positive action of voltage-gated calcium channels blocker amlodipine on vision parameters and retinal blood circulation was proved. Based on clinical researches results declaration into patent of Ukraine on "Tretment method of normotensive open-angle glaucoma patients". Product Description popup.authors Веселовська З.Ф. Маслов В.Ю. Пурнинь О.Е. popup.nrat_date 2020-04-02 Close