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Information × Registration Number 0210U003159, 0108U000465 , R & D reports Title To investigate the basic cellular-molecular mechanisms of infringements of antineoplastic immunity in patients with B-cellular chronic lymphocytic leukaemia. popup.stage_title Head Isakova L. M., Registration Date 25-01-2010 Organization State Institution "Institute of Haematology and Transfusiology AMS Ukraine" popup.description2 Object of research: 73 the patients with B-CLL .Methods: clinical, citochemical , citofluorumetric, immunologic. It is Iinfringements of congenital and adaptive immunity which were characterized by decrease in peripheral blood of amount natural killer cells (imunophenotype is CD16+CD56+) and natural killer Т-lymphocytes (imunophenotype is CD3+CD16+CD56 +), and also quantitative disbalance imunoregulatory subpopulations to which concern Т-helpers/inducers(imunophenotype is CD3+CD4 +) and Т-supressors/cytotoxic limphocytes (imunophenotype is CD3+CD8 +) which are the cores cellular effectors of antineoplastic immunity have been revealed. Changes of parameters testify to functional infringements in B-system immunity of these patients humoralimmunity. It is accompanied by changes enzymatic the status neutrophils and lymphocytes.Medical and social effect. Medicine. Product Description popup.authors Ісакова Л. М. Гордієнко А.І. Дарчук Г.Ф. Загоруйко Н.Л. Звєркова А.С. Павлюк Р.П. Перехрестенко Т.П. Третяк Н.М. Шороп Є.В. popup.nrat_date 2020-04-02 Close